The new drug that could shine a light on the mysteries of MRSA

A new light-activated drug could tackle MRSA infections more effectively than existing antibiotics, researchers say.

They used a type of gel - a hydrogel - to hold the drug and cover infected wounds.

The gel then releases the drug, which is activated by a particular kind of light to kill the bugs. In laboratory studies, the system had a 100 per cent success rate.

More work is needed to see if the same level of eradication can be achieved in patients, but lead researcher Corona Cassidy called its potential 'exciting.'

Infection experts believe MRSA - methicillin-resistant staphylococcus aureus - kills at least 5,000 people a year. It is harmless to healthy people but dangerous to sick patients and those having surgery if it gets under the skin.

It can produce complications such as pneumonia, meningitis, organ failure and fatal blood poisoning.
MRSA is resistant to many commonly-used antibiotics and almost half of patients need more powerful drugs.

Doctors do not apply antibiotics directly to MRSA-infected wounds as the drugs do not penetrate deep enough to have an effect. They may also irritate the surrounding skin, slowing down healing.

But Miss Cassidy and her team at the School of Pharmacy in Queen's University, Belfast, moved away from the antibiotic approach to a system known as photodynamic antimicrobial chemotherapy, or PACT.

Details from the research will be presented today at the British Pharmaceutical Conference in Manchester.

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