Manuel Uribe tipped the scales at a whopping 89.8 stone after a 14-year junk food binge.
The 42-year-old former mechanic, who has been bedridden for six years, stuffed his face with burgers, pizzas and fizzy drinks.
At his heaviest he suffered from lesions and sores on his legs which he bound up with duct tape to stop them from getting infected.
But he is now determined to get back to a healthy weight and after two years of intense dieting he has shed 40.7 stone.
His target weight is now 15.7 stone and his strict diet now consists of fish soup, one grapefruit, half an apple and 18 peanuts.
Manuel, who lives in Moterrey, Mexico, with his fiancée Claudia Solis Miranda and his mother Orilia, started dieting after a tearful TV appeal two years ago where he begged viewers to save his life.
Medical experts from Italy and Spain offered to carry out gastric bypass surgery on him - but he refused and instead accepted the help of US biochemist Dr Barry Sears, who prescribed the high-protein Zone Diet.
By last year he had slimmed down to 60 stone and celebrated by sipping champagne.
But despite spending 14 years gorging junk food, doctors believe Manuel's colossal weight is caused by a hormone imbalance.
One of his nutritionists, Alejandra Garcia, said: "It's about controlling his hormones. It is not some outlandish fad diet. It is simple common sense refined by science."
Manuel, whose story will be told on Extraordinary People: The World's Heaviest Man at 9pm on Five tonight, added: "I feel great. The doctors say I'm healthier than ever."
Before his diet, his usual breakfast would consist of four eggs, rice, beans and tortillas.
He said: "People think that I can eat a whole cow but it's not just overeating, it's also a hormonal problem."
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